Current members in the lab

Studies development of resistance to targeted cancer therapy. 

Investigates effects of Bag3-associated signaling pathways on cancer development.  

Develops a double barcoding system to monitor drug effects on tumors and metastasis. Collaborates with chemists to develop potent antibody-drug conjugates.

Studies how the Hsp70-Bag3 module regulates motility of macrophages and their infiltration into tumors.

Studies a novel mechanism of resistance to a drug irinotecan associated with the accumulation of mutations in non-coding regions. 

Develops double barcoding for shRNA libraries to distinguish between true and false hits. 

Studies how the Hsp70-Bag3 module regulates Hippo Pathway and protein aggregation. Investigates how Bag3 controls nuclear translocation of transcription factors.

Studies how the Hsp70-Bag3 module regulates Unfolded Protein Response and cell death. Uncovers the pathways network regulated by Hsp70-Bag3. 

Develops an approach to predict medicinal properties of plants.  

Studies common pathways that affect drug resistance.  

Studies resistance to topoisomerase inhibitors associated with the accumulation of mutations in non-coding regions.  

Develops an approach to rationally design potent drug combinations. Studies synergy between drugs. 

Studies anti-cancer properties of medicinal plants